Molecular Evolution: The HIV Envelope Protein
نویسندگان
چکیده
منابع مشابه
Envelope gene evolution and HIV-1 neuropathogenesis.
In the era of combined antiretroviral therapy (cART), HIV-associated neurocognitive disorders (HAND) account for 40 to 56% of all HIV+ cases. During the acute stage of HIV-1 infection (<6 months), the virus invades and replicates within the central nervous system (CNS). Compared to peripheral tissues, the local CNS cell population expresses distinct levels of chemokine receptors, which levels e...
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A prophylactic vaccine is needed to slow the spread of HIV-1 infection. Optimization of the wild-type envelope glycoproteins to create immunogens that can elicit effective neutralizing antibodies is a high priority. Starting with ten genes encoding subtype B HIV-1 gp120 envelope glycoproteins and using in vitro homologous DNA recombination, we created chimeric gp120 variants that were screened ...
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Prion protein (PrP) sequences are until now available for only six of the 18 orders of placental mammals. A broader comparison of mammalian prions might help to understand the enigmatic functional and pathogenic properties of this protein. We therefore determined PrP coding sequences in 26 mammalian species to include all placental orders and major subordinal groups. Glycosylation sites, cystei...
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Institute of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, 4 Switzerland 5 Swiss Institute of Bioinformatics, Lausanne, Switzerland 6 Department of Genetics, Smurfit Institute of Genetics, University of Dublin, Trinity College Dublin, 7 Dublin, Ireland 8 Instituto de Biología Molecular y Celular de Plantas (CSIC-UPV), Valencia, Spain 9 Department of Biology, Univ...
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ژورنال
عنوان ژورنال: Evolution: Education and Outreach
سال: 2008
ISSN: 1936-6426,1936-6434
DOI: 10.1007/s12052-007-0023-6